In the present study once daily esomeprazole controlled release tablet was prepared by utilizing carbopol as the primary polymer and different grades of hydroxypropyl methylcellulose (HPMC) as the secondary polymers such as Methocel K4M & Methocel K15 M by direct compression method.Carbopol was kept constant and different amount of Methocel K 4 M & Methocel K15 M was used to develop once daily esomeprazole in the nine proposed formulations (FA1-FC3). The dissolution study of those proposed formulations were carried out in the simulated gastric medium (pH 1.3) for first two hours and then in the simulated intestinal medium (pH 6.8) for 24 hours using USP dissolution apparatus II. The formulation FB2 met the optimum release rate of esomeprazole for 24 hours period of in vitro dissolution study and considered as the best formulation comparing to others. The release kinetics of formulation FB2 very closely followed Higuchi mechanism and zero order kinetics. Mucoadhesive strength study was carried out for the optimized formulation FB2 using goat intestine and shows high mucoadhesive strength. One month stability study was performed for optimized formulation FB2 and complies within the limit.
Loading....